Abstract: Objective: To assess the efficacy of 308nm excimer laser combined with topical tacrolimus in the treatment of facial vitiligo. Methods: Six hundred and fifty six patients were treated with topical tacrolimus twice a day and 308nm excimer laser once or twice a week for 30 times. The patients were followed up for 1 year. Results: The total effective rate of 1630 lesions was 47.12%. The effective rate of the lesions with a duration of illness less than 2 years was 58.10%, which was higher than that for the lesions with a duration of illness more than 2 years (16.6%), with a significant difference (P<0.001). The curative effect for the lesion in the periocular area was 54.96%, while the effect for the perioral lesions was 40.22%, with a significant difference between the two groups (p < 0.0001). Conclusion: The therapeutic effect of 308nm excimer laser combined with tacrolimus in the treatment of facial vitiligo depends on the duration and location of the lesion.

Key words: vitiligo, 308-nm excimer laser;tacrolim