Abstract: Clinical and pathological data of 35 cases with acquired reactive perforating collagenosis collected from 2013 to 2016 was retrospectively analyzed. The ratio of male to female was 1∶1.19. The average age at onset of the disease was 49.5 years. The duration of the disease was diverged significantly. The histopathology shows collagen fibers within the epidermis. Only 20% of the patients were found having systemic disease. The skin lesions were diverse. The misdiagnosis rate was 77% and the disease was most misdiagnosed as prurigo nodularis (13 times) and eczema (10 times).

Key words: acquired reactive perforating collagenosis, clinic, pathology