Abstract: It was previously reported that 82% of the patients with severe monkeypox were HIV infected, and there were also reports that immunocompromised HIV patients died after being infected with the monkeypox virus. This paper reported a case of monkeypox complicated with AIDS, syphilis and local bacterial infection. The patient had poor compliance with ART antiviral therapy, and high HIV viral load, and low immune function. After being infected with monkeypox virus, typical features such as rash, fever, and local lymphadenopathy appeared, and the hospital stay was longer than the average hospital stay of monkeypox in the region. Therefore, patients with low immune function had serious condition, and the hospital stay was longer, which should be paid enough attention to.

Key words: monkeypox, syphilis, AIDS, high HIV load, immunocompromise