Abstract: We analyzed the clinical manifestations and histological characteristics of skin lesions in 3 recently confirmed AIDS patients with monkeypox. All the 3 patients were young men, and there were initial genital rash spread throughout the body, 2 patients with fever, 1 patient with an inguinal lymph node enlargement. The peripheral blood HIV antibody was positive . Pharyngeal swabs, rash swabs and anal swabs and other specimens were positive for monkeypox virus PCR test. The biopsy characteristics were consistent, which revealed piece-meal necrosis in local epidermal whole layer and superficial dermis, and the cells surrounding necrosis were odema and balloon changes, with many neutrophile granulocyte and nuclear dust. There were many infiltration of lymphocytes, neutrophile granulocyte and eosinophils in the dermis.

Key words: monkeypox, AIDS, skin pathology