China Journal of Leprosy and Skin Diseases ›› 2024, Vol. 40 ›› Issue (7): 519-523.doi: 10.12144/zgmfskin202407519

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Update of Janus kinase inhibitors in the treatment of vitiligo

YAN Yuanyuan1, ZHAO Yanxia2, CHENG Yu3   

  1. 1 Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; 2 Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin 300120, China; 3 Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China
  • Online:2024-07-15 Published:2024-06-12

Abstract: In recent years, more studies have shown that JAK-STAT signaling pathway plays an important role in the immune pathogenesis of vitiligo, and JAK inhibitors based on this pathway have shown a strong therapeutic prospect in the treatment of vitiligo. The update of the mechanism, clinical efficacy and safety of JAK inhibitors of vitiligo in recent years are reviewed in this paper.

Key words: vitiligo, JAK-STAT signaling pathway, JAK inhibitors