中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (8): 557-563.doi: 10.12144/zgmfskin202308557

• 论著 • 上一篇    下一篇

A型肉毒毒素局部注射治疗雄激素性秃发的Meta分析

宋黎,唐懿,刘彦麟,杨思雨,陆茂   

  1. 成都医学院第一附属医院皮肤科，四川成都，610500
  • 出版日期:2023-08-15 发布日期:2023-07-19

Meta-analysis of botulinum toxin type A injection in the treatment of androgenetic alopecia

SONG Li, TANG Yi, LIU Yanlin, YANG Siyu, LU Mao   

  1. Department of Dermatology, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China
  • Online:2023-08-15 Published:2023-07-19

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摘要： 近年来， A型肉毒毒素逐渐应用于头痛性脱发、放射性脱发、斑秃及AGA，但有学者认为其疗效及安全性亟待评估。本文对A型肉毒毒素局部注射治疗雄激素秃发的有效性及安全性的相关文献进行了Meta分析。计算机检索the Cochrane library、Pubmed、Web of science、EMbase、中国知网（CNKI）、万方数据库、维普中文科技期刊全文数据库、中国生物医学文献服务系统中从建库至2022年9月的关于A型肉毒毒素治疗雄激素脱发的临床试验，手工检索补全资料。经2名研究人员筛选出纳入的研究并进行文献质量评价，最后对纳入研究采用Revman 5.3软件进行分析，不能Meta分析的资料采用描述性分析。结果共纳入10个临床试验，414例患者。Meta分析显示A型肉毒毒素局部注射可增加毛发密度，可改善患者瘙痒、油腻、头皮屑等主观症状，与常规治疗联用时效果更优(均P<0.05)，局部疼痛是主要的不良反应，无严重不良反应发生。

关键词: A型肉毒毒素, 雄激素性秃发, 毛发密度, Meta分析

Abstract: In recent years, Botulinum toxin type A (BTX-A) has been used to treat headache alopecia, radiation alopecia, alopecia areata and AGA, but some scholars believe that its efficacy and safety need to be evaluated. We evaluate the efficaty and safety of BTX-A injection in the treatment of androgenetic alopecia through mata-analysis. Clinical trial studies of botulinum toxin type A for the treatment of androgenetic alopecia were researched in the Cochrane library, Pubmed, Web of Retrieved from science, EMbase, CNKI, Wanfang Database, Weipu Full-text Database of Chinese Science and Technology Journals, and China Biomedical Literature Service System from the establishment of the database to September 2022. The literature quality was evaluated by two researchers. Finally, Revman 5.3 software was used to analyze the included studies. The result showed 10 studies involving 414 patients were included. Meta-analysis showed BTX-A could increase the hair density and improve the subjective symptoms of itching, greasy, dandruff, etc. and the effect was better when combined with conventional treatment. The main adverse reaction was local pain, and no serious adverse reaction occurred.

Key words: botulinum toxin type A, androgenetic alopecia, hair density, meta-analysis