中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (10): 619-623.

• 综述 • 上一篇    下一篇

神经酰胺代谢途径对皮肤屏障功能影响研究进展

刘媛  解宇环  何丹  林青  孙晓菲   

  1. 云南中医学院，云南昆明,650500
  • 出版日期:2017-10-15 发布日期:2018-12-10
  • 通讯作者: 孙晓菲，E-mail: xiaofeisun@163.com

Update of the effect of ceramide metabolism pathway on skin barrier function

LIU Yuan,  XIE Yuhuan, HE Dan, LIN Qing, SUN Xiaofei.    

  1. Yunnan University of Traditional Chinese Medicine, Kunming 650500, China
  • Online:2017-10-15 Published:2018-12-10
  • Contact: SUN Xiaofei, E-mail: xiaofeisun@163.com

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摘要： 神经酰胺是角质层脂质的主要成分，是反映皮肤屏障功能的关键性物质，其含量的变化会使细胞间脂质结构发生变化，导致皮肤屏障功能障碍，而引发相关皮肤病。本文对神经酰胺的合成、分解、对皮肤屏障功能的影响及相关皮肤病进行综述。

关键词: 神经酰胺, 皮肤屏障, 代谢途径, 酶

Abstract: Ceramide is a major ingredient of the lipid in stratum corneum, the key material, which reflects skin barrier function. The change of content of ceramide can lead to the structure damage of the lipid in stratum corneum, which leads to the skin barrier function damage and skin diseases. The composition, catabolism and the effects on skin barrier function of ceramide is reviewed in this article.

Key words: ceramide, skin barrier, metabolic pathway, enzyme