真核细胞翻译起始因子4E在皮肤基底细胞癌中的表达

Abstract

Abstract: Objective:To detect the expression of eukaryotic translation initiation factor 4E (eIF4E) in basal cell carcinoma (BCC). Methods: The protein and mRNA expressions of eIF4E were detected by PV-9000 immunohistochemistry and real-time PCR in 20 patients with basal cell carcinoma and 20 healthy controls. Results:The MODs in BCC and controls were 0.198±0.031 and 0.096±0.015 respectively and the expression levels of mRNA were 2.32±1.00 and 1.24±0.17, with significant differences (P<0.05). Conclusion:eIF4E may involve in the pathogenesis of BCC.

Key words: basal cell carcinoma, eIF4E, immunohistochemistry, RT-PCR

DENG Yue, LIU Haidong, ZHUANG Le, MA Weiyuan. Expression of eIF4E in basal cell carcinoma[J].China Journal of Leprosy and Skin Diseases, 2016, 32(7): 388-390.

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Expression of eIF4E in basal cell carcinoma

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