Abstract: Objective: To analyze the epidemiological characteristics of syphilis in Shandong Province from 2014 to 2024, providing a theoretical basis for prevention and control strategies. Methods: The temporal and spatial distribution characteristics of syphilis data in Shandong Province from 2014 to 2024 was analyzed in SPSS, Geoda and ArcGIS. Results: The reported incidence of syphilis showed an upward trend (EAPC=3.08, P＜0.01), with latent syphilis exhibiting the fastest growth (EAPC=8.58, P＜0.01). In comparison, the reported incidences of primary, secondary, tertiary and congenital syphilis declined to varying degrees, among which congenital syphilis demonstrated the most significant decrease (EAPC=-15.83, P＜0.01). Spatially, syphilis in Shandong exhibited significant clustering patterns and has changed over time, initially the high-incidence areas concentrated in eastern coastal counties/districts and have gradually expanded to central and western regions in recent years. Conclusion: The syphilis epidemic in Shandong Province presents multiple characteristics such as an overall increase, latent dominance, and the shift of high-incidence areas from east to west. Strategiesof syphilis prevention and control should be transformed from passive detection to active screening and a uniform provincial approach should be shifted to targeted interventions in key regions.

Key words: syphilis, epidemiological characteristics, spatiotemporal distribution