China Journal of Leprosy and Skin Diseases ›› 2023, Vol. 39 ›› Issue (10): 770-773.doi: 10.12144/zgmfskin202310770

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Update of TRPV1 in the pathogenesis and treatment of atopic dermatitis

YAN Hongxia1, HUA Ri2, JIA Xiujuan3, WANG Bailing1, GAO Zhiqing1, ZHANG Xiaofeng4, WU Fenglan1, MU Qiri1   

  1. 1 Department of Dermatology, International Mongolian Hospital of Inner Mongolia, Hohhot 010020, China; 2 Department of Dermatology, Baotou Mongolian Medicine and Traditional Chinese Medicine Hospital, Baotou 014040, China; 3 Inner Mongolia People's Hospital, Hohhot 010010, China; 4 Traditional Chinese Medicine and Mongolian Medicine Research Center of Inner Mongolia, Hohhot 010060, China
  • Online:2023-10-15 Published:2023-10-12

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Abstract: Atopic dermatitis is a common chronic recurrent, itchy and inflammatory skin disease with high incidence rate and complex pathogenesis. TRPV1, as an important member of the transient receptor potential family, participates in the pathophysiology and pathogenesis of various skin diseases. Recent research evidence has also found a strong correlation between TRPV1 and the pathogenesis of atopic dermatitis. Currently, some drugs targeting TRPV1 have achieved good efficacy and safety in treating atopic dermatitis. The update of TRPV1 in the pathogenesis and treatment of atopic dermatitis is reviewed in this paper.

Key words: atopic dermatitis, transient receptor potential family, TRPV1, pathogenesis, treatment