Abstract: The clinical and pathological data of 64 patients with lichen sclerosus (LS) diagnosed by histopathology in the Department of Dermatology in our hospital from January 1, 2016 to June 30, 2020. The average age of the patients was 36.84±17.84 years and the male to female ratio was 1∶2.5. The lesions were located on the vulva in 25 cases (39%) (vulva group) and on other body parts in 39 cases (61%) (non-vulva group)，there was no significant difference in gender and age between the two groups. The clinical misdiagnosis rate of non-vulva group (38.5%) was higher than that of vulva group (12%), with a significant difference (P=0.022). The patients in vulva group was more prone to pruritus, epidermal hyperplasia, telangiectasis and eosinophil infiltration than  in the non-vulva group, with a significant difference (P<0.05). Nine patients underwent dermoscopy, and white-yellowish structureless areas and telangiectasis were seen in 9 cases, follicular plugs in 6 cases and white shiny lines in 7 cases. The study showed the LS lesions located on non-vulvar  is not uncommon and and it is more likely to be misdiagnosed. Dermoscopy plays an auxiliary role in diagnosis.

Key words: lichen sclerosus, clinical, histopathology, dermoscopy