Secukinumab was the first fully human anti-interleukin-17a monoclonal antibody and successfully treated moderate-severe psoriasis. These new targeted medications are becoming more popular, but long-term side effects are not entirely clear. Dyshidrotic eczema and pompholyx are rare variants of dermatitis characterized by vesicles or bullae on the palms, soles and sides of the fingers. At present, the cases of patients with similar skin rashes after using secukinumab in the world have been reported. Herein, we present one case of erythroderma, accompany with dyshidrotic eczema in a patient with secukinumab for psoriasis.

Psoriasis is a chronic recurrent inflammatory skin disease, which often recurs at the remission site of the primary skin lesions. Tissue resident memory T cells (TRM) can reside in the skin for a long time. In recent years, many studies have shown that TRM plays a crucial role in psoriasis recurrence and effective inhibition of TRM may be the key to control psoriasis recurrence. However, the anti-injury and anti-apoptotic characteristics of TRM make it difficult to control the recurrence. In this paper, we reviewed the production and residence of cutaneous TRM and the relationship between TRM and psoriasis recurrence.

Nagashima-Type palmoplantar keratosis (NPPK) is the most common palmoplantar keratosis in Asian population. In 2013, Kubo found that it was caused by homozygous or complex heterozygous mutations in serine protease inhibitor B7 (SERPINB7) by whole exome sequencing, and 15 different pathogenic mutations have been found at present. The typical clinical feature of NPPK is hyperkeratosis. NPPK has a good long-term prognosis, but there is still no standardized treatment. Current studies have found that gentamicin can effectively relieve skin hyperkeratosis and smell in patients with NPPK, but more clinical studies are needed to verify.

Acne vulgaris is a common chronic inflammatory disorder involving pilosebaceous organs. Androgens is well known to play a pivotal role in the initiation of acne. Antiandrogen medicines such as Clascoterone and combined oral contraceptives have already been used in clinic. Besides, some other medicines such as ASC-J9 cream, cyproterone acetate lotion, ketoconazole cream, spironolactone, flutamide, etc. are also promising. The antiandrogen in the treatment of acne is reviewed in this paper.

A 62-year-old male presented with multiple subcutaneous nodules on the left waist and left thigh for 10 mouths. Dermatological examination showed multiple subcutaneous nodules touched on the left waist and left thigh, and there was a small opening in the center of the lateral nodule of left thigh, with a little yellowish white pus. Histopathology showed granulomatous inflammation with large necrosis and small abscess. Gene detection of infectious pathogens showed Tropheryma whipplei. The diagnosis of Tropheryma whipplei infection was made. Surgical resection was performed.

Objective: To determine the effect of clascoterone on androgen-induced human sebocytes proliferation, lipid synthesis and inflammatory factors expression in vitro and explore its anti-acne mechanism. Methods: The immortalized human sebocytes SZ95 were cultrured in vitro and then divided into Dihydrotestosterone (DHT) group, clascoterone group and clascoterone+DHT group. The cell proliferation, intracellular neutral lipids, lipid synthesis-related proteins expression, inflammatory factors and transcription level of cytokines was detected by CCK8, nile red staining and western blot, enzyme-linked immunosorbent assay and RT-qPCR respectively. Results: Compared with the DHT group, the number of cells in the clascoterone+DHT group significantly decreased (P<0.01) after 24-hour treatment. After treated with linoleic acid (LA), the level of neutral lipids in the clascoterone+DHT group was significantly  lower than that in the DHT group (P<0.0001). The lipid synthesis-related proteins such as PPARγ, PLIN2, FASN and SCD1, the transcription levels of IL-1α, IL-1β, IL-6, IL-8 and the corresponding protein levels in the clascoterone+DHT group was significantly  lower than those in the DHT group (Ps<0.05) . Conclusion: Clascoterone has a partly androgen-independent regulatory effect on human sebocytes proliferation, lipid synthesis-related genes and inflammatory factors in vitro, which might be one of anti-acne mechanisms.

Objective: To assess the efficacy and safety of baricitinib in the treatment of patient with progressive vitiligo. Methods: Patients with vitiligo received baritinib from April 2021 to March 2022 due to failure of systemic hormone therapy or refusal to use glucocorticoids were collected and evaluated at 3 and 6 months. Results: 8 patients were collected. After 3 and 6 months of treatment, the significant efficiency was 35.3% and 55.9%, and the total effective rate was 67.6% and 73.5%, respectively. After 6 months of treatment, the efficacy of extremities was lower than that of trunk (total effective rate χ²=7.369, P<0.01) and limbs (total effective rate χ²=4.554, P<0.05).  Conclusion: Baricitinib is effective and safe for progressive vitiligo，which is affected by duration of treatment and location of lesions.

Objective: To assess the efficacy of nail groove reconstruction combined with correction of the nail curl deformity on ingrown paronychia. Methods: 48 patients with severe ingrown paronychia in our department from December 2019 to October 2021 were treated with nail groove reconstruction and combined with correction of the nail curl deformity. The key techniques of the operation included wedge-shaped excision of proliferative granulation tissue to reduce nail fold, then the side tissue of nail fold and nail bed were made at the same level through our suture method; two small rectangular rubber sheets are respectively fixed under the both edges of the nail to passivate the nail edge; two rubber bands was used to pull the two rubber sheets under the nail margin to raise the bilateral margins of the nail for correction the nail curl deformity. Results: All 48 patients (81 big toes) were cured and there was no recurrence after 6 months of follow-up.  Conclusion: The efficacy of nail groove reconstruction combined with nail curl for ingrown paronychia is good.

Objective: To analyze the genotype distribution and clinical characteristics of human papillomavirus (HPV) in male patients. Methods: The data of the patients with HPV positivity from January 2017 to July 2021 in our hospital were collected and analyzed retrospectively. Results: 552 patients and samples were collected. Of 552 samples, HPV6, 11, 16 and 51 were the most common subtypes, with proportions of 35.51%, 23.73%, 16.49% and 10.14% respectively. The proportion of high-risk HPV subtypes accounted for 63.95% (simple high-risk infection+polyinfection). In different types of infection, single infection proportion was 56.88%, multiple infection proportion was 43.12%. In the clinical aspect, of 552 cases, 335 (60.69%) manifested as condyloma acuminatum and the most common subtypes were HPV6 and 11, 7 manifested as bowenoid papulosis and the most common subtypes was HPV16, 210（38.04%） were asymptomatic carriers and the most common subtypes were HPV16,52,58 and 51.  Conclusion: HPV6, 11, 16 and 51 are the most common subtypes of HPV in this study, and the  high-risk HPV proportion and single infection proportion are both high. The propotion of asymptomatic carriers is high and high-risk HPV infection is the main type, which should be noted.

A 27-year-old female presented with papules on the face with itching for 1 month. The patient had been treated with mesotherapy injection in a local beauty salon 4 months ago. Based on the clinical and histological features, the diagnosis of facial foreign body granuloma was made. The patient was given compound betamethasone injection and the lesions subsided.

An 88-year-old male presented with a single dark-brown skin mass on the top of the head for 10 years, with enlargement and ulceration for 1 year. Physical examination showed a 10.2 cm×7.1 cm mass on the top of the head, with irregular shape, clear boundary, irregular edge and bulging nodular hyperplasia, crater ulcer in the center and uneven bottom. The histopathology features were in accordance with trichothecal carcinoma. The patient was treated with surgical excision, with no recurrence after 6-month follow up.

A 68-year-old female presented with skin ulceration in the left knee tibial tuberosity surgical scars for 3 days, with a history of total knee arthroplasty 5 years ago. Routine bacterial culture of wound swabs showed Mycobacterium fortuitum. We thought that the pathogenic bacteria of this case was from the external environment according the course of disease, the image data of the soft tissues infection around the prosthesis, the intact fascia layer. The patient was treated with anti-tuberculosis drugs and a skin graft surgery, and the patient is improving.

Mesenchymal stem cells (MSCs) are pluripotent adult stem cells with the potential for self-renewal, multi-lineage differentiation and immunomodulatory properties. Studies have reported the presence of MSCs in the dermis and epidermis of patients with psoriasis and suggested that MSCs may promote the inflammatory process and psoriatic lesions development through high HLA-Ⅰexpression and low immunosuppressive capacity against CD3+T cells. At present, the safety and efficacy of MSCs infusion have been confirmed in mice psoriasis models induced by imiquimod and clinical trials, but there may be potential risks. The update of MSCs in the treatment of psoriasis is reviewed in this paper.

Background: Eight pm on April 13, 2022,a10:1 mixed test tube was found to be positive in the COVID-19 nucleic acid test site set up outside the hospital. In order to identify the infected case and control the spread of COVID-19 rapidly, we conducted this emergency investigation. Methods: According to the National COVID-19 Control and Prevention Protocol (8th edition), Guideline on Emergency Response to COVID-19 Case Found in Hospital in Shandong Province, and the Emergency Response Plan for COVID-19 in our hospital, information reporting, hospitalblockading, potential COVID-19 cases tracing, close contact screening, environmental sampling and disinfecting, COVID-19 nucleic acid testing and risk assessment were carried out by our team. Results: A female COVID-19 case aged 50 years was identified. She is aodd-jobber who works in the labour market near the hospital. The virus strain was sequenced as Omicron BA.2. A total of 65 close contacts was controlled in a hotel. The COVID-19 nucleic acid test results for all the staff of hospital, environmental samples were negative. The risk of COVID-19 spread was controlled and the hospital restarted of clinical activities as normal at 8 am on April 14 after blockaded for 12 hours. Inthe following 7 days, the staff of the hospital were tested for COVID-19 nucleic acid twice a day, and the results were negative. Then the testing frequency changed to once a day. Conclusion: Formulating detailed and feasible COVID-19 emergency response plans based on the requirements of the public documents and the actual conditions of the hospital, is useful to improve the efficiency of emergency response to COVID-19 cases and save time for control of COVID-19 spread and restart the clinical activities of hospital.

Objective: To summarize the characteristics and dermoscopic images of school-age children with trichotillomania. Methods: The data of 103 patients with trichotillomania in our hospital from June 2017 to June 2021 were collected and analyzed retrospectively. Results: Of 103 patients, 51 were male and 52 were female, with an average age of 10.20 ± 2.75 years. The hair loss were on the crown of the head  (48.5%), unilateral temporal (28.2%), bilateral temporal  (15.5%), frontal (20.4%), occipital (5.8%) and eyebrows (2.9%). Dermoscopic features included black dots (95.1%), broken hair (71.8%), flame hair 58 (56.3%) , blood spots (48.5%) , pigtail-like hair (35%), coiled hairs (27.2%),and spear-like hair (3.9%). Conclusion: The most common site of trichotillomania is the crown of the head and the common dermoscopic characteristics of school-age children with trichotillomania are black spot sign, broken hair, flame hair, blood spots, and pigtail-like hair.

A 64-year-old man presented to our hospital with gradually darkening facial and hand back skin. He had been taking niacinamide, Tripterygium wifordii, dapsone, and minocycline for the past 14 weeks for treatment of bullous pemphigoid. The minocycline was replaced by roxithromycin. At a follow-up visit 42 weeks later, the facial and hand back hyperpigmentation were resolved.

A 38-year-old male presented with erythema with scales on scalp and armpit, fingernails and toenails thickening and discoloration for more than 1 year. Physical examination showed erythema with small scales on scalp and armpit, onycholysis, distal subungual hyperkeratosis, discoloration and pitting on part of nails. Diagnosis of psoriasis vulgaris and nail psoriasis were made and the patient was treated with secukinumab. Lesions disappeared rapidly and obvious improvement was seen in nails changes. No obvious adverse effect and no relapse of skin lesions were seen in 1-year follow-up.

A 73-year-old leper relapsed who had been cured for 41 years. The patient presented with systemic pain erythema, scattered red nodules in different sizes on trunk and limbs, accompanied by systemic fatigue discomfort, facial edema, with no joint pain and no nerve enlargement and pain. The patient was reported to the control institution, and treated with combination chemotherapy drugs with good effective. The patient is continued to be treated in the leprosy village.

A 31-year-old male presented with systemic squamous plaque for 5 years. After receiving tumor necrosis factor inhibitor treatment for 8 months, the rash recurred. Two weeks after drug withdrawal, erythema, papules, scales and fever were relapse. The diagnosis of rythrodermic psoriasis was made, and the skin lesions subsided after a week of treatment with IL-17A antagonist.

Erythema elevatum diutinum (EED) is a rare cutaneous leukocytoclastic vasculitis. Its pathogenesis is not clear, but it is thought to be related to the deposition of circulation immunity compound around blood vessels secondary to infection, hematological diseases and autoimmune diseases. It was reported that 39.4% of EED patients was associated with HIV infection, viral hepatitis, streptococcal infection, paralbuminemia, myelodysplastic syndrome, systemic lupus erythematosus and rheumatoid arthritis. We reported a case of EED with aplastic anemia, and reviewed the clinical characteristics of EED with other systemic diseases through previously reported literature, and preliminarily discussed the correlation among EED, hematological diseases and malignancies.

Retinoids are a kind of derivatives of vitamin A, and have an important role in regulating cell proliferation and differentiation, regulating immunity, inhibiting-inflammation, reducing sebaceous gland secretion, and inducing cell apoptosis. Retinoids are currently divided into four generations and widely used in psoriasis and inflammatory dermatoses, disorders of the sebaceous and apocrine glands, disorders of epidermal differentiation and keratinization, premalignant and malignant lesinons and other diseases. Topical retinoids cause skin reactions, and the adverse reactions of systemic retinoids dermatherapy mainly include mucocutaneous effects, teratogenicity, musculoskeletal effects and impacts on liver function and lipid levels.

Port-wine stain(PWS) is a congenital vascular malformation. Photodynamic therapy (PDT) has been used to treat PWS, especially for large areas, treatment-resistant and purple PWS. However, PDT still caused side effects such as pain, swelling, exudation, and scab. To provide a theoretical basis for the treatment of PWS, this article reviewed the progress of PDT in the treatment of PWS and discussed its advantages and disadvantages.

Morphea-like basal cell carcinoma is the less common subtype of BCC, which is clinically rare. We reported a case of Morphea-like basal cell carcinoma. A 65-year-old female complained of papules and hard spots on the nasal dorsum more than 10 years, enlargement with a small amount of scab for 1 year. Dermatological examination showed a slightly elevated induration, 1.5 cm×2 cm in size, with funiform depression and small pieces of black scab. The histopathological features was in accordance with morphea-like basal cell arcinoma. The lesion was excised.

A 57-year-old woman presented with a slowly growing, smoothsurfaced masss on the right third finger, and the nail dehisced gradually. Histopathology of the mass showed that accompanied by fibroblasts and collagen fiber bundles of cross-trending. Histopathology of right third finger double-layered nails showed the nail plate was flat with a large amount of subungual keratinization, epidermal hyperkeratosis, and focal parakeratosis. The diagnosis of nail loss secondary to periungual fibroma was made and the lesions were excised.

A 5-year-old girl presented with hypopigmented patches all over the body and scattered erythemas for 1 year. The histopathological included epidermal atrophy slightly, lymphocytes presented within the epidermis, and infiltration of lymphocytes in papillary dermis. Immunohistochemistry exhibited that the infiltrating cells were positive for CD3、CD8、CD4 (a few)、Ki-67（10%）, and negative for CD20. The diagnosis of childhood hypopigmented mycosis fungoides was made.

A one-month-old girl presented with red papules and scabs on her head and face gradually increased for 1 month. Dermatological examination showed soybean to pea sized papules, papulovesicles, scabs on his scalp, forehead, trunk and limbs. A few of the rashes have scales, which were not easily to scrape. Histopathological examination revealed edema between epidermal cells, mononuclear cell migration, basal cell liquefaction and degeneration, more mononuclear cell infiltration in the superficial and middle dermis, with large nucleus and rich cytoplasm. DIF: negative for IgG, C3, IgM, IgA between epidermal cells and basement membrane. Immunohistochemistry: weakly positive for CD1a, S100, CD68, positive for Langerin. No treatment was given. The lesions dissipated and no new rash occurred after 1 month follow-up.

A 2-year-old boy presented with an orange patch on the right sole was found for 2 days. Feedback from family members: stink bug are seen in the home. Dermoscopy: Orange pigment on the surface of the plantar skin was calm, with fused intermediate pigments and peripheral pigments distributed along the cutaneous ridge. Th diagnosis of orange pigment spot on sole of foot caused by stink bug was made. Alcohol washing was ineffective, and the stains gradually disappeared after two weeks of follow-up.

A 61-year-old female presented with palmoplantar keratoderma, constricting bands on several fingers and joint contracture for 60 years. Clinical examination showed marked palmoplantar keratoderma, fibrous constricting bands on several fingers, brown polygonal scales on limbs. The patient had neither deafness nor dysgnosia. Her parents were cousins, and her sister had similar symptoms.

The 50-year-old female patient had a history of syphilis for 17 months and paroxysmal headaches for 4 months. Seventeen months ago, the patient was diagnosed as primary syphilis, and received regular treatment and regular visit. The RPR titer decreased by 4 times and the rash subsided for 6-month treatment. Ten months ago, syphilis recurred, and given the regular treatment, the rash subsided after treatment again. Four months ago, he occurred paroxysmal headache, and MRI showed a mass on the right side of head, which was considered as a metastatic tumor. The patient was treated with surgery and the histological examination showed syphilitic gumma. Headache disappeared then the patient was given antisyphilitic treatment.

A 41-year-old male presented with diffuse erythema with severe pruritus for 1 year and multiple lymph node enlargement for 3 months. PET/CT image was consistent with lymphoma, pathology of lymph node showed non-Hodgkin T cell lymphoma, with irregular, twisted, and cerebriform nuclei. Skin pathology showed non-Hodgkin T cell lymphoma presenting with mycosis fungoides. Sézary syndrome was diagnosed according the above examinations and T cell gene rearrangement in peripheral blood. The effect of chemotherapy and other first-line drugs was not good, then the treatment regimen containing brentuximab vedotin was given, with good effect of erythema subsided, pruritus disappeared, lymph nodes decreased.

The main evaluation methods for sensitive skin include subjective, semi-subjective and objective evaluations at present. Treatments mainly involves healthy education on possible causes of disease, using appropriate skin care products, topical calcineurin inhibitors (TCI) and antagonist of transient receptor potential vanilloid 1 (TRPV1), besides, low intensity laser can also reduce uncomfortable feelings of sensitive skin. The update of evaluation methods and treatments of sensitive skin is reviewed in this paper.

A 78-year-old female patient, who misdiagnosed as herpes zoster in a local  hospital，presented with blisters on the right scalp with pain for 3 months. The patient was treated with anti-inflammatory, antiviral, and analgesic therapeutic regimen without obvious effect. The secondary pathology and immunohistochemical staining confirmed a diagnosis as hemangioendothelioma. The patient refused treatment.

Objective: To access the effect and possible mechanism of antihistamine ebastine on atopic dermatitis (AD) mouse model induced by 2,4-dinitrofluorobenzene (DNFB). Methods: Eighteen Balb/c female mice aged 6-8 weeks were randomly divided into treatment group, negative control group and blank group. The AD mouse model was prepared by coating DNFB on the back skin of mice, and the mice in the blank group were not treated. After 2 weeks of modeling, the treatment group was given ebastine of concentration of 0.41 mg/mL, 0.2mL, by gavage, once a day, and the negative control group was given the same amount of normal saline. After 2 weeks of administration, the changes of body weight, skin lesion and scratching behavior of mice were assessed, the thickness of skin lesions and the number of eosinophils were observed by HE staining, and the level of serum interleukin-4 (IL-4) was detected by ELISA. Results: Typical AD lesions such as erythema, edema, exudation, crust and skin thickening appeared in the back skin of the model mice. The weight of mice in the treatment group and the blank group increased after the experiment (P<0.05), but there was no significant change in the negative control group (P>0.05). Compared with the negative control group, there was no significant difference in the score of skin lesion in the treatment group before treatment (P>0.05). After treatment, the score of skin lesion in the treatment group decreased significantly (P<0.05). In addition, the scratching times, epidermal thickness, eosinophil number and serum IL-4 in the treatment group were lower than those in the negative control group (P<0.05). Conclusion: Ebastine has certain therapeutic effect on AD mouse model, which may through inhibiting Th2 immune response in vivo.

Objective: To study the infection situation of Staphylococcus aureus (SA) and drug resistance characteristics of MRSA and MSSA in inpatients that infected with skin and soft tissue infections (SSTIs) in our hospital. Methods: The data of SSTIs inpatients who underwent bacterial culture and drug sensitivity test in our hospital from January 1, 2018 to December 31, 2020 were collected and the recall factor and disease distribution of SA, MRSA and differences in drug resistance between MRSA and MSSA were analyzed. Results: A total of 1455 SSTIs inpatients were collected, including 323 SA infection (22.2%). Of 323 SA cases, 72 (22.3%) were positive for MRSA. The recall factor of MRSA showed an increasing trend from 2018 to 2020. The patients positive for MRSA were most pemphigus, bullous pemphigoid, eczema, psoriasis and erythroderma. The drug resistance rates of MRSA to 11 antibacterial agents such as azithromycin, penicillin, erythromycin, clarithromycin and tetracycline were significantly higher than those of MSSA, with significant differences (Ps<0.05), and there was no significant difference between MRSA and MSSA on drug resistance rates of cotrimoxazole, clindamycin and gentamicin (Ps>0.05).  Conclusion: The recall factor of SA in SSTIs is high in our hospital, and the proportion of SA in MRSA is high, and the drug resistance rate of MRSA to most antibacterial drugs is significantly higher than MSSA.

Objective: To discover novel gene mutation responsible for porokeratosis by exon sequencing combined with somatic mutation detection. Methods: Peripheral blood DNA was collected for whole exon sequencing from 29 patients with porokeratosis who had failed to identify mutations by target region sequencing on known genes, and DNA was extracted from somatic cells for Sanger sequencing. Results: Splice region mutations were detected in the peripheral blood DNA of three patients by whole-exome sequencing, including one novel identified mutation on the MVK gene. Mutations were detected in the somatic DNA of 5 patients by Sanger sequencing. Conclusion: In this study, three splice site mutations were identified, including a novel mutation, and five cases of simple somatic mutations were found, enriching the mutation spectrum and mutation forms of porokeratosis genes, and there was no novel mutated genes identified.

A 58-year-old male presented with purplish red flat papules around the body accompanied by itching for 2 months. Histopathology and immunopathology features were consistent with pemphigoid lichen planus. The patient was treated with oral administration of acitretina A capsule 30 mg, once a day, tripterygium wilfordii 20 mg, 3 times a day, topical administration of halometasone and hascinide. The blisters were subsided, and the color of the rash was obviously lighter than before after 15-day follow up.

Fish stab wound granuloma is a granulomatous injury caused by Mycobacterium marinum infection after a fish stab wound. The upper limbs are the most common site of infection. Usually, the reported cases are mostly nodules and erythema on the skin surface. It is rare to involve deep structures such as tendons, bones, and joints. Two cases of tenosynovitis caused by Mycobacterium marinum infection are reported.

Shiitake dermatitis is also known as flagellate dermatitis. The main clinical manifestations are striped and linear flagellate erythema. Most patients are accompanied by itching and have a history of eating mushrooms. We report three cases of shiitake dermatitis. Case 1 had a history of eating undercooked mushrooms twice. Case 2 had a history of eating plenty of flammulina mushrooms in sauce 48 hours before onset. Case 3 had a history of eating undercooked mushrooms one day before onset.

A 27-year-old female presented with scalp plaque for 2 months. Histopathology showed that the tumor grew horizontally and vertically, involving epidermis, dermis and superficial adipose tissue. Cellular atypia and pathological mitotic phases were noted. Then extensive resection of the tumor was performed. Histopathology showed that the tumor cells in the epidermis grew like paget's disease, and there were still tumor cells remaining. Immunohistochemistry: EMA (+), AR (-), CAE (-), ER (-) of tumor cells, the ratio of Ki67 positive cells was 30%. The diagnosis of sebaceous carcinoma was made. Resection should be performed again, supplemented by radiotherapy or chemotherapy.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease, often involving multiple systems, accompanied by abnormal glucose metabolism and lipid metabolism. Hydroxychloroquine has been found to have a protective effect on blood glucose and blood lipid in SLE patients while treating the disease which as one of the basic drugs for systemic lupus erythematosus. The update of the effect of hydroxychloroquine on dyslipidemia and blood glucose in systemic lupus erythematosus patients is reviewed in this article.